We aimed to investigate the immediate effect of best practice education (with and without pain science messages) and structure-focused education on reassurance among people with rotator cuff–related shoulder pain. We conducted a 3-arm, parallel-group, randomised experiment. People with rotator cuff–related shoulder pain were randomised (1:1:1) [...]
Short-stay joint replacement programmes are used in many countries but there has been little scrutiny of safety outcomes in the literature. We aimed to systematically review evidence on the safety of short-stay programmes versus usual care for total hip (THR) and knee replacement (KR), and [...]
Pain is one of the most burdensome symptoms in people with cancer, and opioid analgesics are considered the mainstay of cancer pain management. For this review, the authors evaluated the efficacy and toxicities of opioid analgesics compared with placebo, other opioids, nonopioid analgesics, and nonpharmacologic [...]
We investigated differences in cumulative incidence of first distant recurrence following non-metastatic breast cancer over a time period when new adjuvant therapies became available in Australia. We conducted a health record linkage study of females with localized (T1-3N0) or regional (T4 or N+) breast cancer [...]
In clinical practice, the co-existence of endometriosis and gastrointestinal symptoms is often observed. Using large-scale datasets, we report a genetic correlation between endometriosis and irritable bowel syndrome (IBS), peptic ulcer disease (PUD), gastro-esophageal reflux disease (GORD), and a combined GORD/PUD medicated (GPM) phenotype. Mendelian randomization analyses [...]
Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy world-wide, affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise lifestyle optimisation, medications, septal reduction therapies and rarely cardiac transplantation. Advances in our understanding of disease-causing genetic variants in HCM and their associated molecular mechanisms have [...]
The present study examines the patterns of hospital and emergency department services in conjunction with both pre and post diagnostic periods of CT use, which has not been evaluated to date in adult patients with cancer. The cohort makes use of whole of population data [...]
Basic science has found limited evidence from small studies of genuine positive effects on health and wellbeing outcomes, caused by positive treatment expectations, known as placebo effects.1 Naturally, many researchers and clinicians are curious about how to harness the placebo effect in clinical practice to improve [...]
Few studies have investigated the association between obesity, preoperative weight loss and postoperative outcomes beyond 30- and 90-days post-arthroplasty. This study investigated whether body mass index (BMI) and preoperative weight loss in people with obesity predict postoperative complications and patient-reported outcomes 6 months following total knee [...]
High breast density on mammography is a well-established risk factor for a breast cancer diagnosis. There is interest in whether breast density might also predict how aggressive a breast cancer is, including the likelihood of causing death. If mammographic features at the time of cancer [...]