Randomised Control Trial (RCT)

Using the Behaviour Change Wheel to identify barriers and targeted strategies to improve adherence in randomised clinical trials: The example of MEL-SELF trial of patient-led surveillance for melanoma – Deonna M. Ackermann et al.

2024-06-04T12:14:37+10:00Cancer, Clinical trials, Melanoma, Patient-led surveillance, Publications, Randomised Control Trial (RCT), Research|

Adherence to self-management interventions is critical in both clinical settings and trials to ensure maximal effectiveness. This study reports how the Behaviour Change Wheel may be used to assess barriers to self-management behaviours and develop strategies to maximise adherence in a trial setting (the MEL-SELF [...]

Remotely delivered physiotherapy is as effective as face-to-face physiotherapy for musculoskeletal conditions (REFORM): a randomised trial – Hannah G Withers et al.

2024-04-07T14:10:21+10:00Musculoskeletal, Physiotherapy, Publications, Randomised Control Trial (RCT), Research, Virtual Care/Telehealth|

The REFORM trial was a randomised, controlled non-inferiority trial in which participants were randomised to either remotely delivered physiotherapy or usual care . The assessor and statisticians were blinded. The protocol was published and the trial was prospectively registered. Participants were recruited from five public [...]

The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective – Paul Glasziou et al.

2023-12-04T14:09:43+11:00Publications, Randomised Control Trial (RCT), Research, Research ethics|

Controlled trials are the principal means of investigating the effects of therapeutic and prophylactic interventions. They can be designed to avoid biases, and so provide clear and reliable insights into 'what works' under ideal circumstances. Controlled trials can, however, also generate evidence to inform decisions [...]

Crowdsourcing and automation facilitated the identification and classification of randomized controlled trials in a living review – Mohammed Mujaab Kamso et al.

2023-12-04T12:27:08+11:00AI, Publications, Randomised Control Trial (RCT), Research|

The objective of this study is to evaluate an approach using automation and crowdsourcing to identify and classify randomized controlled trials (RCTs) for rheumatoid arthritis (RA) in a living systematic review (LSR). Records from a database search for RCTs in RA were screened first by [...]

Feasibility of Symptom monitoring WIth Feedback Trial (SWIFT) for adults on hemodialysis: a registry-based cluster randomized pilot trial – Neeru Agarwal et al.

2023-12-01T15:47:41+11:00Audit and feedback, Kidney, PROMS, Publications, Randomised Control Trial (RCT)|

Patients with kidney failure on hemodialysis (HD) experience considerable symptom burden and poor health-related quality of life (HRQoL). There is limited use of patient reported outcome measures (PROMs) in facility HD units to direct immediate care, with response rates in other studies between 36 to [...]

Commentary on Kraiss et al.: Read the label – improving the applicability of systematic reviews by coding and analysis of intervention elements – Paul P. Glasziou & Nicholas A. Zwar

2023-12-01T13:13:43+11:00Health policy, Publications, Randomised Control Trial (RCT), Research|

While controlled trials establish an intervention's effectiveness, poor intervention descriptions can obscure substantial variation. To address this problem, Kraiss and colleagues extend the systematic review process with several additional steps. Although important for clinical and policymaking in addiction, the considerable effort needed will be a [...]

Psychosocial outcomes and health service use after notifying women participating in population breast screening when they have dense breasts: a BreastScreen Queensland randomised controlled trial – Brooke Nickel, Nick Ormiston-Smith, Lisa Hammerton, et al.

2023-10-23T15:10:51+11:00Breast cancer, Breast density, Publications, Randomised Control Trial (RCT), Research|

Robust evidence regarding the benefits and harms of notifying Australian women when routine breast screening identifies that they have dense breasts is needed for informing future mammography population screening practice and policy. Objectives of this RCT are to assess the psychosocial and health services use [...]

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