Research Archives - Page 2 of 5

Participant recruitment and attrition in surgical randomised trials with placebo controls versus non-operative controls: a meta-epidemiological study and meta-analysis – Pragadesh Natarajan et al.

Lucia Marcello2024-06-04T13:02:19+10:00Placebos, Publications, Randomised Control Trial (RCT), Research, Risk, Surgery|

Placebo control trials are the gold standard for determining the true therapeutic effect of interventions. However, placebo trials commonly face difficulties in participant recruitment due to a lack of willingness to participate especially in surgical placebo trials due to its inherently invasive nature and higher [...]

It’s OK to Move! Effect of a Brief Video on Community Confidence in Activity Despite Back Pain: A Randomized Trial – Edel T. O’Hagan et al.

Lucia Marcello2024-06-04T12:47:53+10:00Low back pain, Musculoskeletal, Pain, Public comprehension, Publications, Randomised Control Trial (RCT)|

Participants aged 18 years and over, with and without low back pain, were recruited via the social media channel Facebook, to view either a humorous video, a neutral video, or to no intervention. The videos were delivered online, explained evidence-based management for low back pain, [...]

Using the Behaviour Change Wheel to identify barriers and targeted strategies to improve adherence in randomised clinical trials: The example of MEL-SELF trial of patient-led surveillance for melanoma – Deonna M. Ackermann et al.

Lucia Marcello2024-06-04T12:14:37+10:00Cancer, Clinical trials, Melanoma, Patient-led surveillance, Publications, Randomised Control Trial (RCT), Research|

Adherence to self-management interventions is critical in both clinical settings and trials to ensure maximal effectiveness. This study reports how the Behaviour Change Wheel may be used to assess barriers to self-management behaviours and develop strategies to maximise adherence in a trial setting (the MEL-SELF [...]

Evidence for overdiagnosis in noncancer conditions was assessed: a metaepidemiological study using the ‘Fair Umpire’ framework – Sharon Sanders et al.

Lucia Marcello2024-04-07T15:30:38+10:00Overdiagnosis, Overtesting, Overuse, Publications, Research, Tests|

To our knowledge, this is the first methodological review of studies concerned with overdiagnosis in noncancer conditions. We identified 132 studies identifying or quantifying overdiagnosis of a wide range of noncancer conditions. We applied a novel framework that uses the concept of ‘‘Fair Umpires’’ to [...]

Reply to Ballou and Kube – Caitlin M. P. Jones et al.

Lucia Marcello2024-04-07T14:28:50+10:00Clinical trials, Pain, Placebos, Publications, Research, Research ethics|

Thank you for the invitation to respond to a letter received about our article titled “Time to reflect on open-label placebos and their value for clinical practice.”Letter authors Ballou and Kube disagree with some of our criticisms of currently available research on open-label placebos (OLPs). [...]

Remotely delivered physiotherapy is as effective as face-to-face physiotherapy for musculoskeletal conditions (REFORM): a randomised trial – Hannah G Withers et al.

Lucia Marcello2024-04-07T14:10:21+10:00Musculoskeletal, Physiotherapy, Publications, Randomised Control Trial (RCT), Research, Virtual Care/Telehealth|

The REFORM trial was a randomised, controlled non-inferiority trial in which participants were randomised to either remotely delivered physiotherapy or usual care . The assessor and statisticians were blinded. The protocol was published and the trial was prospectively registered. Participants were recruited from five public [...]

Participant characteristics and reasons for non-consent to health information linkage for research: experiences from the ATHENA COVID-19 study – Kim Greaves et al.

Lucia Marcello2024-02-13T14:12:53+11:00COVID-19, Ethical considerations, Patient-led surveillance, Primary Care, Publications, Research, Research ethics|

The linkage of primary care, hospital and other health registry data is a global goal, and a consent-based approach is often used. Understanding the attitudes of why participants take part is important, yet little is known about reasons for non-participation. The ATHENA COVID-19 feasibility study [...]

Corporate Influences on Science and Health—the Case of Spinal Cord Stimulation – Adrian C. Traeger & Lisa A. Bero

Lucia Marcello2024-02-13T13:27:54+11:00Conflicts of interest, Ethical considerations, Musculoskeletal, Pain, Publications, Research ethics, Spinal, Treatment|

Corporations have been developing tactics to undermine independent science for decades. In the 1950s, on learning of the damaging effects of tobacco on health, the tobacco industry used campaigns of criticism to defend their products and the substantial revenue they were generating. Corporations could effectively [...]

Correction: Exploring the Integration of Environmental Impacts in the Cost Analysis of the Pilot MEL-SELF Trial of Patient-Led Melanoma Surveillance – Jake T. W. Williams et al.

Lucia Marcello2024-02-13T13:25:11+11:00Cancer, Carbon neutral, Correction, Melanoma, Patient-led surveillance, Publications, Sustainable health care|

In this article the Methods section of the Abstract was incorrectly given as “Economic costs were calculated alongside a randomised trial using standard cost analysis methodology from a societal perspective. Environmental impacts were calculated using a type of carbon footprinting methodology called process-based life cycle [...]

Setting new research in the context of previous research: some options – Paul Glasziou, Mark Jones & Mike Clarke

Lucia Marcello2024-02-13T13:07:08+11:00Ethical considerations, Publications, Research|

If a new clinical trial is to be justifiable both scientifically and ethically it should be designed in the light of an assessment of relevant previous research, ideally a systematic review. When its findings are reported, these should be set in the context of updated [...]

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