We evaluated the relative effects of newer versus older medications for neonatal conditions and trends in margin of superiority across generations. We assessed network meta-analyses (NMAs) on neonatal pharmacological interventions identified from MEDLINE, Cochrane, and PROSPERO. Interventions were chronologically arranged based on the earliest study [...]
Multimodal analgesia regimens are recommended for the postoperative period after hip and knee replacement surgeries. However, there are no data on practice patterns for analgesic use in the immediate postoperative period after hip and knee replacements in Australia. The objective of this study is to [...]
The CRISTAL trial (a cluster randomized, crossover, non-inferiority trial of aspirin compared to low molecular weight heparin for venous thromboembolism prophylaxis in hip or knee arthroplasty, a registry nested study) was designed to investigate the efficacy and safety of aspirin compared with enoxaparin for the [...]
Although paracetamol (acetaminophen) combined with other analgesics can reduce pain intensity in some pain conditions, its effectiveness in managing low back pain and osteoarthritis is unclear. This systematic review investigated whether paracetamol combination therapy is more effective and safer than monotherapy or placebo in low [...]
Existing guideline recommendations suggest considering corticosteroids for adjunct treatment of cellulitis, but this is based on a single trial with low certainty of evidence. The objective was to determine if anti-inflammatory medication (non-steroidal anti-inflammatory drugs [NSAIDs], corticosteroids) as adjunct cellulitis treatment improves clinical response and [...]
Non-drug interventions are recommended for chronic condition prevention and management yet are underused in clinical practice. Understanding barriers and enablers to using non-drug interventions may help implement non-drug interventions in primary care. We aimed to conduct an overview of reviews to identify and summarise common [...]
The management of low back pain commonly includes pharmacological management. Some clinical practice guidelines for managing low back pain now recommend avoiding some medicines, such as opioid analgesics and gabapentinoids (pregabalin, gabapentin), as the benefit often does not outweigh the harms. In people with work-related [...]
Low health literacy is associated with worse health outcomes, including for cardiovascular disease (CVD). However, general practitioners (GPs) have limited support to identify and address patient health literacy needs in CVD prevention consultations. This study explored GPs’ experiences of patient health literacy needs during CVD [...]
Diagnostic uncertainty, risk perceptions, time constraints, and pressure from resident/family members and nurses have been identified as potential barriers to reducing antibiotic prescribing in residential aged-care facilities. The current study investigated the relationship between nurses’ anxiety, clinical tolerance of uncertainty, and behaviors that favor antimicrobial [...]
Prescribers perceive interprofessional tensions and specifically, pressure from nurses to prescribe antibiotics as a significant barrier to reducing overprescribing in RACFs. The primary aim of the current study was to develop a scale that measures nursing behaviours related to antibiotic initiation in RACF. As expected, [...]