With over 50% of women suffering from at least one episode of urinary tract infection (UTI) each year and an increasing prevalence of antimicrobial resistance, efforts need to be made to clearly identify the evidence supporting potential non-drug interventions. This study aims to compare the [...]
Non-drug interventions are recommended for chronic condition prevention and management yet are underused in clinical practice. Understanding barriers and enablers to using non-drug interventions may help implement non-drug interventions in primary care. We aimed to conduct an overview of reviews to identify and summarise common [...]
Deprescribing is the process of a healthcare professional reducing or stopping an inappropriate medication. Statins, commonly prescribed to prevent cardiovascular events, pose uncertain benefits and potential harms for older adults, making deprescribing a preference-sensitive decision. Deprescribing studies typically ask general questions about deprescribing preferences; however, [...]
This study aimed to evaluate whether voluntary and mandatory prescription drug monitoring program (PDMP) use in Victoria, Australia, had an impact on prescribing behaviour, focusing on individual patients' prescribed opioid doses and transition to prescribing of nonmonitored medications.
Deprescribing can be an appropriate intervention when a person’s medications shift towards an unfavourable benefit-to-harm ratio due to changes in an older adult’s medications, health conditions, preferences and treatment goals. To elicit an individual’s preferences and to understand their goals of care, it is essential [...]
The risk–benefit balance of opioids versus placebo, paracetamol, NSAIDs, and local or systemic anesthetics is uncertain. Opioids may have equivalent pain outcomes compared with NSAIDs, but evidence on comparisons of harms is very uncertain and heterogeneous. Although factors such as route of administration or dosage [...]
In the Netherlands, de-implementation of five non-recommended hospital LBP treatments, if at all, took several decades. Although de-implementation was substantial, slow de-implementation has likely resulted in considerable waste of resources and avoidable harm to many patients in Dutch hospitals.
Understanding barriers and enablers to monitoring and deprescribing opioids will enable the development of tailored interventions to improve both practices. To perform a qualitative evidence synthesis of the barriers and enablers to monitoring ongoing appropriateness and deprescribing of opioids for chronic non-cancer pain (CNCP) and [...]
Deprescribing is the process of reducing or discontinuing unnecessary or harmful medicines. To address the ‘opioid epidemic’, clinical practice guidelines now discourage the initial prescription of opioid analgesics for chronic non-cancer pain and strategies such as the introduction of Prescription Drug Monitoring Programs may reduce [...]
Long term opioid therapy for non-cancer pain has been much debated because of concerns that the harms may outweigh benefits. What has received less attention is how long term should be defined and whether the label has any value for patients, doctors, or researchers.