Clinical trials Archives - Wiser Healthcare

Prioritisation of clinical trial learning needs of musculoskeletal researchers: an inter-disciplinary modified Delphi study by the Australia & New Zealand musculoskeletal clinical trials network – Stephanie R Filbay et al.

Lucia Marcello2024-07-31T16:38:27+10:00Clinical trials, Musculoskeletal, Publications, Randomised Control Trial (RCT), Research|

There is a need to increase the capacity and capability of musculoskeletal researchers to design, conduct, and report high-quality clinical trials. The objective of this study was to identify and prioritise clinical trial learning needs of musculoskeletal researchers in Australia and Aotearoa New Zealand. Findings [...]

Supporting study registration to reduce research waste – Marija Purgar et al.

Lucia Marcello2024-07-31T16:17:14+10:00Clinical trials, Guidelines, Publications, Research|

An estimated 82-89% of ecological research and 85% of medical research has limited or no value to the end user because of various inefficiencies. We argue that registration and registered reports can enhance the quality and impact of ecological research. Drawing on evidence from other [...]

Estimating a Minimal Important Difference for the EQ-5D-5L Utility Index in Dialysis Patients – Amanda N. Siriwardana et al.

Lucia Marcello2024-06-12T18:02:59+10:00Clinical trials, Kidney, PROMS, Publications, Treatment|

The EQ-5D-5L is a commonly used health-related quality of life instrument for evaluating interventions in patients receiving dialysis; however, the minimal important difference (MID) that constitutes a meaningful treatment effect for this population has not been established. This study aims to estimate the MID for [...]

Using the Behaviour Change Wheel to identify barriers and targeted strategies to improve adherence in randomised clinical trials: The example of MEL-SELF trial of patient-led surveillance for melanoma – Deonna M. Ackermann et al.

Lucia Marcello2024-06-04T12:14:37+10:00Cancer, Clinical trials, Melanoma, Patient-led surveillance, Publications, Randomised Control Trial (RCT), Research|

Adherence to self-management interventions is critical in both clinical settings and trials to ensure maximal effectiveness. This study reports how the Behaviour Change Wheel may be used to assess barriers to self-management behaviours and develop strategies to maximise adherence in a trial setting (the MEL-SELF [...]

Reply to Ballou and Kube – Caitlin M. P. Jones et al.

Lucia Marcello2024-04-07T14:28:50+10:00Clinical trials, Pain, Placebos, Publications, Research, Research ethics|

Thank you for the invitation to respond to a letter received about our article titled “Time to reflect on open-label placebos and their value for clinical practice.”Letter authors Ballou and Kube disagree with some of our criticisms of currently available research on open-label placebos (OLPs). [...]

Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study – Brooke Nickel, Kirsten McCaffery, Jesse Jansen, et al.

Krista Verlis2023-10-23T15:05:42+11:00Breast cancer, Clinical trials, Health literacy, Publications|

We found that public awareness of DCIS remains very low, but women developed reasonable understanding of DCIS following a short informational presentation. There was substantial support for offering the option of de-escalated treatment for low-risk DCIS, especially among older women. If clinical trials are to [...]

Clinical trials

Prioritisation of clinical trial learning needs of musculoskeletal researchers: an inter-disciplinary modified Delphi study by the Australia & New Zealand musculoskeletal clinical trials network – Stephanie R Filbay et al.

Supporting study registration to reduce research waste – Marija Purgar et al.

Estimating a Minimal Important Difference for the EQ-5D-5L Utility Index in Dialysis Patients – Amanda N. Siriwardana et al.

Using the Behaviour Change Wheel to identify barriers and targeted strategies to improve adherence in randomised clinical trials: The example of MEL-SELF trial of patient-led surveillance for melanoma – Deonna M. Ackermann et al.

Reply to Ballou and Kube – Caitlin M. P. Jones et al.

Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study – Brooke Nickel, Kirsten McCaffery, Jesse Jansen, et al.

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