Wiser Healthcare is a research collaboration involving The University of Sydney, Bond University, Monash University and international colleagues. It is funded by the Australian National Health and Medical Research Council, through both its Centres for Research Excellence scheme and its Program Grant scheme. It aims to conduct research that will reduce overdiagnosis and overtreatment in Australia and around the world. Overdiagnosis and overtreatment occur when routine medical tests and treatments do more harm than good. Wiser Healthcare will investigate the cause and size of the problem and test new solutions, in the areas of cancer, cardiovascular disease and musculoskeletal disorders. We will particularly focus on overdiagnosis caused by imaging (like CT scans and MRI scans), testing biomarkers (for example, blood tests like the Prostate Specific Antigen test), and genetic tests. Here you can find out about our plans, read our work, see the evidence about overdiagnosis, and get help to make decisions, whether you are a clinician, a policymaker, or a citizen considering your own healthcare.